Northbound lanes on Interstate 65 are closed from mile-markers 41 to 55 following a two-vehicle crash involving a semi-tailer and SUV near mile-marker 51.
The semi-trailer overturned and caught fire after colliding with the SUV, Indiana State Police Sgt. Stephen Wheeles said.
Minor injuries were reported, Wheeles said.
Police are encouraging motorists to seek an alternative route. Seymour police were blocking the north ramp to prevent motorists from entering a stalled I-65.
Look here for updates.